TRISOMY 19 MOSAICISM
Trisomy of chromosome 19 is very rare. Trisomy 19 conceptions have not been observed in the large case reports of chromosomal mosaicism discovered on chorionic villus sampling (Hahnemann & Vejerslev 1997). Hsu et al (1997) reported on 1 case of trisomy 19 mosaicism diagnosed on amniocentesis. The outcome for this case was normal.
Uniparental Disomy (UPD 19)
There are no reports of imprinted genes on chromosome 19 (Ledbetter & Engel, 1995).
Link to What is UPD?
- HUGO Chromosome 19 - Chromosome 19 specific sites
Human Chromosome 19 - Provides links to gene maps, sequences, associated genetic disorders, nonhuman genetic models, identified genes, research efforts and laboratories, and other information as available. Links are very scientific.
Hahnemann JM, Vejerslev LO. ( 1997) European collaborative research on mosaicism in CVS (EUCROMIC)--fetal and extrafetal cell lineages in 192 gestations with CVS mosaicism involving single autosomal trisomy. American Journal of Medical Genetics 70(2):179-87. PubMed
Hsu LY, Yu MT, Neu RL, Van Dyke DL, Benn PA, Bradshaw CL, Shaffer LG, Higgins RR, Khodr GS, Morton CC, Wang H, Brothman AR, Chadwick D, Disteche CM, Jenkins LS, Kalousek DK, Pantzar TJ, Wyatt P. (1997) Rare trisomy mosaicism diagnosed in amniocytes, involving an autosome other than chromosomes 13, 18, 20, and 21: karyotype/phenotype correlations. Prenatal Diagnosis 17(3):201-42 PubMed
Ledbetter DH, Engel E. (1995) Uniparental disomy in humans: development of an imprinting map and its implications for prenatal diagnosis. Human Molecular Genetics 4:1757-1764 PubMed